In a major leap toward self-reliance in defense technology, India is set to develop its very own fifth-generation fighter jet—the Advanced Medium Combat Aircraft (AMCA) . In a historic move, Defence Minister Rajnath Singh has approved an innovative execution model for the indigenous stealth fighter programme. This model brings together Hindustan Aeronautics Limited (HAL) and private industry players in a competitive framework, marking a significant shift in how India approaches military aviation manufacturing. This bold initiative comes at a critical time, as China has already fielded two fifth-generation fighters , and reports indicate it will supply 40 J-35 stealth jets to Pakistan . Against this backdrop, fast-tracking the AMCA has become an urgent national security imperative. AMCA: India’s Indigenous Stealth Fighter Dream The AMCA project , spearheaded by the Aeronautical Development Agency (ADA) under the Defence Research and Development Organisation (DRDO) , received its l...
Yamanaka Factors and Their Significance Introduction Yamanaka Factors are four specific transcription factors—Oct4, Sox2, Klf4, and c-Myc—that play a crucial role in reprogramming somatic (adult) cells into induced pluripotent stem cells (iPSCs). These factors enable the transformation of differentiated cells back into a pluripotent state, where they can develop into any cell type in the body. Key Details of Yamanaka Factors 1. The Four Yamanaka Factors Oct4 (Octamer-binding transcription factor 4): Maintains pluripotency and prevents differentiation in embryonic stem cells. Sox2 (SRY-box transcription factor 2): Works with Oct4 to regulate genes necessary for maintaining stem cell properties. Klf4 (Kruppel-like factor 4): Regulates cell proliferation and differentiation, essential for cell reprogramming. c-Myc (Cellular myelocytomatosis oncogene): Enhances cell growth and proliferation, contributing to the efficiency of reprogramming. Applications of Yamanaka Factors 1. Regenerati...