SciTech Express

Yamanaka Factors and Their Significance Introduction Yamanaka Factors are four specific transcription factors—Oct4, Sox2, Klf4, and c-Myc—that play a crucial role in reprogramming somatic (adult) cells into induced pluripotent stem cells (iPSCs). These factors enable the transformation of differentiated cells back into a pluripotent state, where they can develop into any cell type in the body. Key Details of Yamanaka Factors 1. The Four Yamanaka Factors Oct4 (Octamer-binding transcription factor 4): Maintains pluripotency and prevents differentiation in embryonic stem cells. Sox2 (SRY-box transcription factor 2): Works with Oct4 to regulate genes necessary for maintaining stem cell properties. Klf4 (Kruppel-like factor 4): Regulates cell proliferation and differentiation, essential for cell reprogramming. c-Myc (Cellular myelocytomatosis oncogene): Enhances cell growth and proliferation, contributing to the efficiency of reprogramming. Applications of Yamanaka Factors 1. Regenerati...

Nano Urea – A Breakthrough or a Concern for Crop Yields? Introduction Nano Urea, developed by the Indian Farmers Fertiliser Cooperative (IFFCO) , is a nanotechnology-based fertilizer that aims to enhance nitrogen uptake in plants. However, recent studies suggest that its continued use may reduce rice and wheat yields , raising concerns over its long-term sustainability. About Nano Urea Development : Created by IFFCO , a leading fertilizer cooperative in India. Aimed at providing an efficient and eco-friendly nitrogen source for crops. Composition & Properties : Contains 4% nitrogen in nano form. Particle Size : 20-50 nm , which enhances absorption and efficiency . Higher surface area and number of particles per unit area than conventional urea. Potential Benefits of Nano Urea Higher Nutrient Use Efficiency (NUE) Improves nitrogen absorption, reducing excess fertilizer use. Environmental Benefits Reduces nitrogen loss through leaching and gaseous emissions . Minimizes groundwate...