SciTech Express

In the relentless battle against cancer, scientists are continuously uncovering new mechanisms that allow tumors to grow and evade treatment. One of the most groundbreaking discoveries in recent years is the role of extrachromosomal DNA (ecDNA) in promoting cancer progression and drug resistance. Recently, three landmark studies published in Nature have shed light on how ecDNA contributes to the aggressive nature of tumors and their ability to resist chemotherapy. In this, we will explore the significance of ecDNA in cancer biology, how it drives drug resistance, and what these findings mean for future treatments. We’ll also answer some frequently asked questions to help demystify this complex topic. What Is Extrachromosomal DNA (ecDNA)? Extrachromosomal DNA refers to DNA fragments that exist outside the traditional chromosomal structure within the cell nucleus. Unlike chromosomal DNA, ecDNA is not bound to the typical linear chromosomes but instead forms circular or other irregular s...