In a landmark moment for India's space ambitions, Indian astronaut Shubhanshu Shukla has blasted off to the International Space Station (ISS) as part of the Axiom-4 mission , marking the country's return to human spaceflight after a 41-year hiatus . This historic launch from NASA’s Kennedy Space Center in Florida has not only reignited national pride but also officially kickstarted India’s human spaceflight programme . The mission, operated by Axiom Space , includes a four-member international crew that will spend 14 days in orbit , conducting scientific research, outreach programs, and various commercial activities. This momentous occasion places India among a select group of nations capable of sending humans into space and reflects the growing prowess of the Indian space sector . A New Chapter: Shubhanshu Shukla and India’s Astronautical Comeback The last Indian to go to space was Rakesh Sharma in 1984, aboard the Soviet spacecraft Soyuz T-11. Now, in 2025, Shubhanshu...
Yamanaka Factors and Their Significance Introduction Yamanaka Factors are four specific transcription factors—Oct4, Sox2, Klf4, and c-Myc—that play a crucial role in reprogramming somatic (adult) cells into induced pluripotent stem cells (iPSCs). These factors enable the transformation of differentiated cells back into a pluripotent state, where they can develop into any cell type in the body. Key Details of Yamanaka Factors 1. The Four Yamanaka Factors Oct4 (Octamer-binding transcription factor 4): Maintains pluripotency and prevents differentiation in embryonic stem cells. Sox2 (SRY-box transcription factor 2): Works with Oct4 to regulate genes necessary for maintaining stem cell properties. Klf4 (Kruppel-like factor 4): Regulates cell proliferation and differentiation, essential for cell reprogramming. c-Myc (Cellular myelocytomatosis oncogene): Enhances cell growth and proliferation, contributing to the efficiency of reprogramming. Applications of Yamanaka Factors 1. Regenerati...