Yamanaka Factors and Their Significance
Yamanaka Factors and Their Significance Introduction Yamanaka Factors are four specific transcription factors—Oct4, Sox2, Klf4, and c-Myc—that play a crucial role in reprogramming somatic (adult) cells into induced pluripotent stem cells (iPSCs). These factors enable the transformation of differentiated cells back into a pluripotent state, where they can develop into any cell type in the body. Key Details of Yamanaka Factors 1. The Four Yamanaka Factors Oct4 (Octamer-binding transcription factor 4): Maintains pluripotency and prevents differentiation in embryonic stem cells. Sox2 (SRY-box transcription factor 2): Works with Oct4 to regulate genes necessary for maintaining stem cell properties. Klf4 (Kruppel-like factor 4): Regulates cell proliferation and differentiation, essential for cell reprogramming. c-Myc (Cellular myelocytomatosis oncogene): Enhances cell growth and proliferation, contributing to the efficiency of reprogramming. Applications of Yamanaka Factors 1. Regenerati...