In a world increasingly shaped by technological advancement, ensuring gender equality in STEM (Science, Technology, Engineering, and Mathematics) is no longer a choice—it’s a necessity. Recognizing this, the Indian Institute of Technology (IIT) Delhi launched a pioneering initiative titled ‘Manasvi’ , a STEM mentorship programme for high school girls . The programme, unveiled in New Delhi today, is spearheaded by the institute’s Academic Outreach and New Initiatives Office . Manasvi is not merely an educational engagement; it is a transformative platform aimed at inspiring and empowering young girls to pursue careers in STEM, fields traditionally dominated by men. At the heart of Manasvi lies the ambition to address the deep-rooted gender disparity in STEM education and careers . Despite producing the largest number of science graduates globally, India continues to see disproportionately low female representation in STEM careers —a statistic that underscores the urgent need for su...
Nobel Prize in Medicine 2024: Discovery of MicroRNA and Gene Regulation
Introduction
The Nobel Prize in Physiology or Medicine 2024 has been awarded to Victor Ambros and Gary Ruvkun for their groundbreaking discovery of microRNA (miRNA) and its crucial role in post-transcriptional gene regulation. This discovery has revolutionized our understanding of gene expression, cellular development, and disease mechanisms.
We will delve into gene regulation, the function of microRNA, its implications in disease diagnostics, oncogenesis, and immune response, and the broader significance of this remarkable discovery.
What is Gene Regulation?
Gene regulation is the process by which cells control the timing, location, and amount of gene expression. This mechanism ensures that different cells (muscle cells, nerve cells, etc.) express unique sets of proteins, allowing them to perform specialized functions.
Key Aspects of Gene Regulation:
- The human genome contains about 20,000 genes, but not all genes are expressed at the same time.
- Different organs and tissues consist of distinct cell types, even though they share the same genetic material.
- Regulatory processes determine which genes are active or inactive at a given time.
Discovery of MicroRNA (miRNA) by Victor Ambros and Gary Ruvkun
Historical Context
Prior to 1993, scientists believed that gene regulation was primarily controlled by specialized proteins known as transcription factors, which bind to specific DNA regions to regulate mRNA production.
However, Ambros and Ruvkun's discovery challenged this notion by introducing a new class of non-coding RNA molecules—microRNAs (miRNAs)—that regulate gene expression after transcription.
Key Findings
- In 1993, Ambros and Ruvkun discovered microRNA (miRNA) while studying mutant Caenorhabditis elegans nematodes.
- They found that microRNA binds with mRNA, preventing it from being translated into proteins or leading to mRNA degradation.
- Unlike transcription factors, microRNAs act post-transcriptionally, making them a crucial component of gene regulation.
What is MicroRNA (miRNA)?
MicroRNA is a small, non-coding RNA that plays a significant role in regulating gene expression.
Functions of MicroRNA:
- Regulates Gene Expression: miRNAs bind to mRNA and either degrade it or prevent its translation into proteins.
- Controls RNA Transcription: While proteins in the nucleus regulate RNA transcription, microRNAs regulate mRNA degradation and translation in the cytoplasm.
- Maintains Cellular Function: Different types of cells express specific microRNAs to maintain their specialized roles.
Significance of the Discovery
1. Understanding Cellular Development
- MicroRNAs play a key role in stem cell renewal and differentiation.
- They help determine which genes are expressed during embryonic development.
2. Role in Immune Response
- miRNAs help regulate innate and adaptive immunity.
- They influence T-cell development and immune system activation.
3. MicroRNA and Cancer (Oncogenesis)
- Abnormal microRNA activity is linked to cancer development.
- Some miRNAs function as tumor suppressors, preventing the conversion of healthy cells into cancer cells.
- Others act as oncogenes, promoting tumor growth and metastasis.
4. Disease Diagnostics and Therapeutics
- miRNAs serve as biomarkers for diseases like cancer, neurodegenerative disorders, and cardiovascular diseases.
- Therapeutic interventions using microRNA-based drugs are being explored.
Related Concept: Reverse Transcriptase (RTs)
Reverse transcriptase is an enzyme used by viruses like Klebsiella pneumoniae to bind RNA and facilitate reverse transcription.
Key Features of Reverse Transcriptase (RTs):
- RNA-dependent DNA polymerase, which synthesizes DNA from an RNA template.
- Plays a critical role in viral replication and is targeted in antiviral drug development.
Future Prospects: How This Discovery Shapes Medical Science
1. Advancements in Personalized Medicine
- Understanding microRNA networks can lead to tailored treatments for genetic disorders.
- miRNA-based therapies are being researched for treating cancer, diabetes, and neurodegenerative diseases.
2. Development of RNA-Based Vaccines
- MicroRNA-based approaches could enhance the effectiveness of RNA vaccines.
- They may provide long-term immunity against viruses by regulating immune response.
3. Targeting miRNAs for Gene Therapy
- Scientists are exploring the potential of microRNA inhibitors (antagomirs) to block disease-associated miRNAs.
- This approach may revolutionize treatments for cancer, autoimmune disorders, and metabolic diseases.
Conclusion
The 2024 Nobel Prize in Medicine honors Victor Ambros and Gary Ruvkun for their revolutionary work on microRNA and gene regulation. Their discovery has transformed our understanding of cellular development, immune response, cancer biology, and disease diagnostics. With ongoing research into RNA-based therapies, their work paves the way for future breakthroughs in personalized medicine and gene therapy.